PQQ -- The Best Nutrients Helpful for
Mitochondria Dysfunction
What is Mitochondria?
Mitochondria (sing. mitochondrion) are organelles, or parts of a eukaryote cell. It found inside the body’s cells, mitochondria are responsible for producing our primary source of energy, adenosine triphosphate (ATP). ATP provides at least 95% of the cellular energy that powers all living functions. But, if you have a defect in the pathways that the mitochondria usually functions with, you're going to have symptoms in the muscle, in the brain, sometimes in the kidneys as well; many different types of symptoms. And we probably don't know all of the different diseases that mitochondrial dysfunction causes.
Nutrients Helpful for Mitochondria dysfunction
PQQ
Coenzyme Q10 is a key cofactor and component of the mitochondrial electron transport chain.
• the main role of CoQ10 is its involvement in the transfer of electrons along the multiple complexes of the mitochondrial electron transport chain.
Alpha-lipoic acid acts as a critical cofactor in mitochondrial α-keto acid dehydrogenases, and thus it is important in mitochondrial,
oxidative-decarboxylation reactions.
L-carnitine is directly involved in the transport of fatty acids into the mitochondrial matrix for subsequent β-oxidation, but it also functions
in removal of excess acyl groups from the body and in the modulation of intracellular coenzyme A (CoA) homeostasis.
• L-carnitine deficiency disorders are associated with reduced mitochondrial function, insulin resistance, and coronary artery disease
NADH functions as a cellular redox cofactor in over 200 cellular redox reactions and as substrate for certain enzymes. In the mitochondria,
NADH delivers electrons from metabolite hydrolysis to the electron transport chain, but in its reduced form, it can also act as a strong
antioxidant.
• Its deficiency results in pellagra, which is characterized by dermatitis, diarrhea, dementia, and eventually death.
• The usual route of dietary supplementation has historically been via NADH precursors, such as niacin, nicotinic acid, or nicotinamide, but recently, microcarriers have been used to stabilize oral NADH so that it can be directly ingested in large doses and absorbed in the gastrointestinal system.
Phospholipids: Oral membrane phospholipids can increase mitochondrial function and decrease fatigue in chronic fatigue syndrome,
fibromyalgia syndrome, and other fatiguing conditions, including natural aging.
• Oral administration of NT Factor (for 12 weeks resulted in a 35.5% reduction in fatigue and 26.8% increase in mitochondrial function
• membrane phospholipids (2000 mg/d), CoQ10 (35 mg/d), microencapsulated NADH (35 mg/d), L-carnitine (160 mg/d), α-ketoglutaric acid (180 mg/d), into an oral supplement (ATP Fuel) can help restore mitochondrial function and reduce intractable fatigue in patients with chronic illnesses
PQQ stimulates mitochondrial biogenesis
• Bioactive compounds reported to stimulate mitochondrial biogenesis are linked to many healthbenefits such increased longevity, improved energy utilization, and protection from reactive oxygen species.
• Studies have shown that mice and rats fed diets lacking in pyrroloquinoline quinone (PQQ) havereduced mitochondrial content.
• Exposure of mouse Hepa1-6 cells to 10-30 microm PQQ for 24-48 h resulted in increased citrate synthase and cytochrome C oxidase activity, Mitotracker staining, mitochondrial DNA content, and cellular oxygen respiration.
• PQQ exposure stimulated phosphorylation of CREB at serine 133, activated the promoter of PGC1alpha, and increased PGC-1alpha mRNA and protein expression.
• Consistent with activation of the PGC-1alpha pathway, PQQ increased nuclear respiratory factor activation (NRF-1 and NRF-2) and Tfam, TFB1M, and TFB2M mRNA expression.
• The ability of PQQ to stimulate mitochondrial biogenesis accounts in part for action of this compound and suggests that PQQ may be beneficial in diseases associated with mitochondrial dysfunction.
PQQ increase in mitochondrial efficiency in Human
• When humans supplement PQQ (0.075-0.3mg/kg for one week oncedaily),
• urinary lactate decreased by 15% along with a reduction in urinary pyruvic acid.
• A minor reduction of fumarate was noted, but other Kreb's cycle intermediates (Isoaconitate, Citric acid, 2-oxoglutarate, and succinate) were not altered in the urine.
• A nonsignificant decreasing trend in urinary 4-hydroxyphenylacetate was noted with PQQ; decreases in this and other urinary metabolites tend to suggest increased β-oxidation rates.
• It was hypothesized, on the assumption that urinary metabolites reflect cellular energy status, that this indicated an increase in mitochondrial efficiency.
How Does Pyrroloquinoline Quinone disodium salt (PQQ) Work?
Mitochondria are the powerhouses of the cell and produce the vast majority of all cellular energy (ATP). PQQ activates a key transcription factor protein (CREB) and directly stimulates Mitochondrial Biogenesis, which is the growth and replication of new mitochondria. Stronger mitochondria, and more of them, produce more cellular ATP and thereby, users of PQQ may feel higher levels of natural energy.
For many years, researchers thought Pyrroloquinoline Quinone disodium salt (PQQ) is a type of vitamin. However, research done over the last few years has revealed that Pyrroloquinoline Quinone disodium salt is a nutrient with vitamin-like qualities that has the capacity to act as a co-factor or enzyme booster in the reduction-oxidation process which involves the transfer of electrons between two species. In simple words, PQQ binds itself with quinoproteins present in the body and works in collaboration with them to get rid of the free radicals. A research study found quinoproteins to be 100 times more effective than Vitamin – C as an anti-oxidant. Recent studies have also revealed that PQQ affects energy transfer and cellular metabolism by increasing the total number of mitochondria within the body. Exposure to Pyrroloquinoline Quinone disodium salt improves the energy expenditure while decreasing plasma triglycerides. It relieves cardiac ischemia and alleviates neuronal loss and cell death. It is these important facts that have caused a sudden rise in the popularity of Pyrroloquinoline Quinone disodium salt in recent years.
Does Pyrroloquinoline Quinone disodium salt (PQQ) Really Work?
The answer is yes. An extensive body of clinical studies and research have been conducted to study and document the benefits of PQQ. Many of the results that show why the promising potential of PQQ may not be a secret for much longer.
Where You Can Get Pyrroloquinoline Quinone disodium salt (PQQ)?
With people becoming more and more aware of the benefits of pyrroloquinoline quinone disodium salt (PQQ, the demand for pyrroloquinoline quinone disodium salt (PQQ) supplements has increased greatly in the market. This has led to manufacturing companies vying with each other to produce high-quality supplements to grab share in the market. If you are a health supplements manufacturer planning to foray into the pyrroloquinoline quinone disodium salt (PQQ) supplements market, you must ensure that you are getting the highest-quality pyrroloquinoline quinone disodium salt (PQQ) powder. Sourcing good-quality material is the first step in ensuring the success of any business.
If you are looking for a place to buy pyrroloquinoline quinone disodium salt (PQQ) powder in bulk, the one company you can blindly trust for sourcing raw material is Cofttek. The company, owing to its strong research team and dedicated sales department, has established a worldwide presence in only a short amount of time — it has clients and partners around the world. The pyrroloquinoline quinone disodium salt (PQQ) produced by the company comes in big batches of 25 kgs and is sourced from highest-quality ingredients, thereby ensuring that the supplements produced from it can be trusted for quality and efficacy. If you want to buy pyrroloquinoline quinone disodium salt (PQQ) in bulk, the only place to shop is cofttek.com.
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