Palmitoylethanlamide -- A Natural Body-Own Anti-Inflammatory
Why is PEA Safe and Natural?
PEA is a natural substance produced by the body and found in various foods. It is not an opioid. It is not addictive. Preliminary studies indicate that PEA does not develop pharmacological tolerance or gradually lose effectiveness over time as occurs with opioids. It has been shown to be safe for patients with no reported serious side effects and it is considered to lack acute or chronic toxicity. It does not interfere with other medication therapies nor does it trigger drug-drug interactions. There are no known contraindications for PEA, and patients with reduced kidney and liver function can be treated with PEA, as its metabolism is localized and cellular and independent of kidney and liver functions. As with many medications, the safety with long term use over 60 days has not been well studied although thete are reports in the literature of long term use with no problems identified.
Based on the totality of the evidence reviewed, there is a lack of adverse effects with doses of PEA as high as 1200 mg of microPEA per day. The most common regimen studied was 300 mg twice a day, although a sizeable amount of evidence also supports doses of 1200 mg/day. Adverse side effects have been reported to be absent. In summary, available data from animal and human studies support the safety of PEA in general, and of microPEA specifically, in products intended for human and companion animal consumption.
Why do we choose micronized PEA or ultra-micronized PEA?
PEA does not dissolve well in water and as such the rate at which it dissolves in the stomach and intestine is often the rate-limiting step for oral absorption and bioavailability. The rate at which PEA dissolves is influenced by, among other factors, it’s particle size and therefore it is usually micronized or ultra-micronized. (manufactured in very large particle size) in order for it to dissolve more rapidly. As compared to naıve PEA (particle size profile ranging between 100 and 700 lm), micronized and ultramicronized PEA differ in their particles size profile (2–10 lm and 0.8–6 lm at most, respectively). Micronization and ultramicronization processes yield different crystalline structures with higher energy content and largeer particle size which result in better diffusion and distribution of these molecules.
Viruses such as influenza and other respiratory viruses activate an immune response in the human body which includes antiviral and pro-inflammatory responses. The extent of this response is influenced by several factors and explains why one person can experience mild symptoms from the same cold or flu virus whilst another can experience more severe symptoms and illness. Infections with particularly virulent respiratory viruses may also trigger excessive and uncontrolled production of inflammation-producing chemicals contributing to a more severe illness presentation and potential complications.
Palmitoylethanolamide (PEA) is an endogenously produced molecule with well established anti-inflammatory properties for chronic and neuropathic pain. However, it was originally explored as a therapy for the common cold and influenza within six double-blind, placebo-controlled trials in adults and children. These trials were able to demonstrate the efficacy of PEA in both the prevention and treatment of colds and influenza when taken in a supplemental form.
How does PEA work in Immune system?
After an infection with the influenza virus, the immune system reacts by an increased production of many cytokine-patterns. One pattern is related to a proinflammatory response and a second one to an antiviral response.
Infections with virulent influenza viruses together with an aberrant and excessive cytokine production are linked to increased morbidity and mortality. Increased production of specific inflammatory cytokines, such as the tumor necrosis factor (TNF)-α, interleukin- (IL-) 1, IL-6, and IL-10, is characteristic during an influenza infection. More virulent viruses are also associated with rapid and sustained induction of inflammatory cytokines and such an early dysregulation of the host response is seen as contributing to the severity and outcome of the infection.
The increased production of proinflammatory cytokines, hypercytokinemia, is thus a clear player in the disease progression and death of patients infected by influenza viruses. Recently, it was demonstrated that highly elevated levels of serum IL-6 and IL-10 in A (H1N1) patients may also lead to disease progression.
Overactive and nonfunctional hyper induction of proinflammatory cytokines might therefore play a key role in the symptomatology and may lead to increased morbidity and mortality. PEA is widely known for its anti-inflammatory activity and to date more than 60 PubMed indexed papers discuss this property of PEA. Its inhibitory action on TNF-alpha secretion is sufficiently documented . But PEA has a much wider modulating effect on interleukins.
For instance, recently PEA was shown to significantly attenuate the degree of intestinal injury and inflammation and to inhibit proinflammatory cytokine production (TNF-α, IL-1β), adhesion molecules (ICAM-1, P-selectin) expression, and NF-κB expression . PEA also significantly decreases inflammation caused by ischemia-reperfusion injury, a pathological state characterized by a strong enhanced interleukin-cascade. As PEA downmodulates a number of proinflammatory cytokines, this could very well be the reason for the decreased influenza and common cold symptomatology in individuals treated with PEA.
Side Effects & Safety
When taken by mouth: Taking palmitoylethanolamide is POSSIBLY SAFE for most adults when used for up to 3 months. Possible side effects, such as upset stomach, are very rare. There isn't enough reliable information to know if palmitoylethanolamide is safe to use for longer than 3 months.
When applied to the skin: There isn't enough reliable information to know if PEA is safe to use or what the side effects might be.
Special Precautions & Warnings:
Pregnancy and breast-feeding: There isn't enough reliable information to know if palmitoylethanolamide is safe to use when pregnant or breast feeding. Stay on the safe side and avoid use.
Where Should I Buy Micronized Palmitoylethanolamide (PEA) Powder in Bulk?
If you are planning to foray into the PEA supplements markets, now is the perfect time to do so. Though curiosity, as well as the demand for this product, is increasing, there aren’t many companies catering to this demand. However, if you want to set up a Palmitoylethanolamide supplements company, the first you must do is find a raw materials supplier than you can trust and rely on. This brings us to an important question: where should I buy Palmitoylethanolamide (PEA) powder in bulk?
The answer is Cofttek. Cofttek is a supplement raw materials manufacturer that came into existence in 2008. The company takes immense pride in its highly-skilled R&D team that works round the clock to ensure that the raw material being supplied to clients is of very high quality. More importantly, the company invests heavily on biotechnology and analytical testing. All the products sold by the company are created in their large-scale, high-tech biochemical factory that boasts of mature supplier systems and latest technical facilities. It is this commitment that the company has made to produce high-quality raw materials that has made Cofttek a well-recognized name in the raw material market. Today, it has clients across the world.
The Palmitoylethanolamide powder supplied by the company comes in batches of 25 kgs (Palmitoylethanolamide (PEA) Powder). More importantly, the company has a dedicated sales team. So, all your queries and concerns will always be dealt with at priority. If you are looking to buy Palmitoylethanolamide powder in bulk, this is the only place to shop: cofttek.com.
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