The Histoty of Oleoylethanolamide (OEA)
What’s the Oleoylethanolamide (OEA)?
Oleoylethanolamide (OEA) is an endogenous peroxisome proliferator-activated receptor alpha (PPAR-α) agonist. It is a naturally occurring ethanolamide lipid that regulates feeding and body weight in vertebrates ranging from mice to pythons.
OEA is a shorter, monounsaturated analogue of the endocannabinoid anandamide, but unlike anandamide it acts independently of the cannabinoid pathway, regulating PPAR-α activity to stimulate lipolysis.
OEA is produced by the small intestine following feeding in two steps. First an N-acyl transferase (NAT) activity joins the free amino terminus of phosphatidylethanolamine (PE) to the oleoyl group (one variety of acyl group) derived from sn-1-oleoyl-phosphatidylcholine, which contains the fatty acid oleic acid at the sn-1 position. This produces an N-acylphosphatidylethanolamine, which is then split (hydrolyzed) by N-acyl phosphatidylethanolamine-specific phospholipase D (NAPE-PLD) into phosphatidic acid and OEA. The biosynthesis of OEA and other bioactive lipid amides is modulated by bile acids.
OEA has been demonstrated to bind to the novel cannabinoid receptor GPR119. OEA has been suggested to be the receptor's endogenous ligand.
OEA has been reported to lengthen the life span of the roundworm Caenorhabditis elegans through interactions with lysomal molecules.
The Histoty of Oleoylethanolamide
What it’ll do for you: “Studies report that OEA can turn off the switch in the central nervous system for hunger,” explains Roberta Anding, RD, ADA spokesperson and sports dietitian for the Houston Texans.
Before 2001, there wasn’t much research on OEA. But that year, Spanish researchers broke down the lipid and studied how it’s made, where it’s used and what it does. They tested the effect of OEA on the brain (of rats) by injecting it directly into the brain ventricles. They found no effect on eating and confirmed that OEA does not act in the brain, but rather, it triggers a separate signal that affects hunger and eating behavior.
So how does it work then? OEA works to activate something called PPAR and simultaneously ramps up fat-burning and decreases fat storage. When you eat, OEA levels increase and your appetite decreases when the sensory nerves that link to your brain tell it that you’re full. There have been many studies proving this effect. A good one: In 2004, Danish researchers looked at rats that had been starved for 24 hours. They administered OEA (10 mg/kg of body weight) and found that food intake was reduced by 15.5 percent.
Additionally, a 2009 study at the University of California reported that OEA also affects memory-enhancing signals in the part of the brain that remembers emotional events. The researchers said that when placed in a maze, the OEA helped animals remember where they found a nice, fatty meal. This memory trigger is believed to be a key aspect in human’s earlier primitive lifestyle but also hypothesizes that fatty foods could help in the formation of long-term memories.
The raw material supplier of Oleoylethanolamide (OEA)
One can purchase an OEA drug from a reputed and proficient drug store located nearby your dwelling place or can even buy it by ordering online. But one has to be very alert in this respect as all the suppliers of this drug might not be genuine.
So, always check the reputation and the proficiency of the online drug stores and for that, it is always advisable to go through the details of the reviews of the experienced purchasers. Be sure about the packaging of the product like whether it is properly sealed or not to avoid any type of contamination which can result in some dangerous issues in the health front.
Oleoylethanolamide (oea) in the form of powder
OEA in its original state is not found in the form of tablets or capsules. However, you can buy OEA powder in bulkin the market if required. This powder form is incorporated in the finished product by regularizing it to 15 % OEA or 50 % OEA oleic acid. The blueprint of Cima OEA is maintained between 90 % to 95 % especially among the purchasers of Europe and the United States.
Buy Oleoylethanolamide (OEA) powder in bulk
You can place an online order for bulk purchase of powder or can even buy from reputed local stores. Storage is pretty simple in the case of OEA powder. You need to store it at room temperature. But, it should not come in contact with the moisture or direct sun rays. So, you need to keep it tightly sealed in a cool and dry place.
STABILITY
Uses of OEAcan help you in many ways! For this reason, highly recommendable to everyone as it has no side effects. It can even induce a healthy lifestyle within your family making all of you grow and glow in shape, style, and with esteem and confidence. Keeping and maintaining your body in shape, especially for those who are a little bit obese, will not only make you feel happy but will also make others feel happy and proud too about you.
OEA will also help you to release out mental stress helping you to create a positive impression in others’ minds. Thus, instead of feeling upset and unhappy, it is high time to take an action and start using OEA and you will be extremely amazed to see its magical powers and you will feel healed and caressed.
References
(1).Pi-Sunyer FX, Aronne LJ, Heshmati HM, Devin J, Rosenstock J. Effect of rimonabant, a cannabinoid-1 receptor blocker, on weight and cardiometabolic risk factors in overweight or obese patients: RIO-North America: a randomized controlled trial. The Journal of the American Medical Association. 2006; 295(7):761–775.
(3).Sarro-Ramirez A, Sanchez-Lopez D, Tejeda-Padron A, Frias C, Zaldivar-Rae J, Murillo-Rodriguez E. Brain molecules and appetite: the case of oleoylethanolamide. Central Nervous System Agents in Medicinal Chemistry. 2013;13(1):88–91.